Endocrine Abstracts

Purpose: To evaluate the outcome of different Radioactive iodine-131 activity range for the treatment of hyperthyroidism assessed at 6 and 12 months.Material/method: We retrospectively reviewed data of patients who received Radioiodine treatment for benign thyroid disorder at our center between 2013 to 2015. Indication for treatment, radioiodine activity administered, type of hyperthyroidism, and biochemical outcome of thyroid function at 6 and 12 months...

Vitamin D deficiency has become a worldwide problem, although vitamin D deficiency had associated with increased insulin resistance, obesity and HbA1c in patients with T2D.It is uncertain whether vitamin D deficiency causes diabetes or its due to confounding. The active metabolite 1α,25-dihydroxyvitamin D3 may affect the receptors of pancreatic β-cells and hence affect insulin secretion, also it may have impact on insulin sensitivity.<p cla...

Introduction: Severe hypercalcaemia is a medical emergency which can result in severe cardiovascular and neurological dysfunction. Pathophysiological mechanisms of hypercalcaemia include increased osteoclastic activity, osteolytic bone metastasis, extra-renal activation/production of 1,25 hydroxyvitamin D and decreased urinary calcium excretion. Understanding these mechanisms is important to guide the diagnostic process and the long-term management of hypercalcaemia.<p cla...

According to the seventh edition of diabetes atlas, 415 million persons all over the world are diabetics requiring more than 680 billion US $ annually for their management. Diabetes affects middle and low socio economic countries than developed countries. The ADA/EASD guidelines included drug price as one of the criteria to choose from different classes. Incretin based therapy are new classes for treatment of T2 DM with low incidence of hypoglycemia and modest weight loss, but...

Background: It was noted in the last few years there was an increased incidence of vasculitis and vasculitic reactions in patients with thyrotoxicosis. Those vasculitic reactions ranged from simple purpuric skin lesion to sever intra-alveolar hemorrhage and even to Steven Johnson Syndrome, Most of those vasculitic reactions occurred in patients receiving propylthiouracil or methimazole. But many other cases were detected in thyrotoxic patients even be...

Background: Insulin autoimmune syndrome (IAS) is characterised by spontaneous hypoglycaemia in the absence of exogenous insulin administration and high serum levels of immunoreactive insulin along with high titres of insulin antibodies. Although it is the third leading cause of hypoglycaemia in Japan, it is very rare in the western world. We present the first reported case of IAS in UK.Case report: A 27-year-old lady from south east-Asian background pres...

Background: Hepatitis C virus is common in Egypt and its prevalence varies from 10 to 17%. Beside its harmful effect on the liver, it can lead to variable other effects on various organs and tissues known as the extrahepatic manifestations of HCV. hepatitis C virus induced thyroid diseases in the form of thyroiditis resulting in hypofunction or even hyperfunction of the gland. thyroid disease was found to be of immune nature. Also diabetes which is often termed hepatogenous di...

Background: Post-treatment monitoring of thyroid cancer depends on risk stratification for future recurrence or possible extra-thyroidal metastasis. Current guidance suggests that patients with favourable prognostic factors and a low likelihood of recurrence can be effectively monitored in community settings. This study explores the safety of community-based surveillance for stable low-risk thyroid cancer patients discharged from specialised thyroid clinic.<p class="abstex...

Introduction: LADA (Latent Autoimmune Diabetes in Adults), is defined by the association of diabetes after 30 years, the presence of antibodies against pancreatic beta cells and the non-use of insulin therapy within 6 months of diagnosis. Graves’ disease is the first cause of hyperthyroidism associating thyrotoxicosis, goiterand exophthalmos with a prevalence 5 times higher in women.Case report: 37-year-old female patient with no notable history, la...

Background: Polycystic ovary syndrome (PCOS) is a common disorder, yet not fully understood. Multiple hormonal and metabolic factors influence the pathophysiology of disease; resulting in various phenotypic characteristics among PCOS population. The luteinizing hormone/choriogonadotropin receptor (LHCGR, OMIM: 152790) is a G protein- coupled receptor mapped on chromosome 2p16.3; its coding region comprises 10 exons separated by 10 introns which transcript to protein w...